Lower Airway Microbiota

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Airway Microbiota and Allergic Diseases: Clinical Implications

Bronchial Asthma is an airway disease with variable degrees of bronchial mucosal inflammation and intermittent episodes of airway obstruction and bronchial hyperesponsivness. That asthma is a syndrome consisting of different phenotypes has been recognized for a long time by clinicians [1]. New evidence indicates that the composition of airway microbiota differs in states of health and disease. ...

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Community dynamics and the lower airway microbiota in stable chronic obstructive pulmonary disease, smokers and healthy non-smokers.

RATIONALE The role bacteria play in the progression of COPD has increasingly been highlighted in recent years. However, the microbial community complexity in the lower airways of patients with COPD is poorly characterised. OBJECTIVES To compare the lower airway microbiota in patients with COPD, smokers and non-smokers. METHODS Bronchial wash samples from adults with COPD (n=18), smokers wit...

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Inflammation and Airway Microbiota during Cystic Fibrosis Pulmonary Exacerbations

BACKGROUND Pulmonary exacerbations (PEx), frequently associated with airway infection and inflammation, are the leading cause of morbidity in cystic fibrosis (CF). Molecular microbiologic approaches detect complex microbiota from CF airway samples taken during PEx. The relationship between airway microbiota, inflammation, and lung function during CF PEx is not well understood. OBJECTIVE To de...

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Oral and airway microbiota in HIV-infected pneumonia patients.

Despite the increased frequency of recurrent pneumonia in HIV-infected patients and recent studies linking the airway bacterial community (microbiota) to acute and chronic respiratory infection, little is known of the oral and airway microbiota that exist in these individuals and their propensity to harbor pathogens despite antimicrobial treatment for acute pneumonia. This pilot study compared ...

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Atopic asthmatic immune phenotypes associated with airway microbiota and airway obstruction

BACKGROUND Differences in asthma severity may be related to inflammation in the airways. The lower airway microbiota has been associated with clinical features such as airway obstruction, symptom control, and response to corticosteroids. OBJECTIVE To assess the relationship between local airway inflammation, severity of disease, and the lower airway microbiota in atopic asthmatics. METHODS ...

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ژورنال

عنوان ژورنال: Frontiers in Pediatrics

سال: 2019

ISSN: 2296-2360

DOI: 10.3389/fped.2019.00393